Challenging Management Of Pure Squamous Cell Carcinoma Of Gallbladder With Liver Metastasis: A Case Report

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Published: Mar 15, 2026

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N Tilawatu
a:1:{s:5:"en_US";s:6:"Doctor";}
N Ezmas
General Surgeon
F Ahmad
Pathologist

Abstract

Pure squamous cell carcinoma of the gallbladder is a rare form of gallbladder carcinoma. The
presentation is either by accidental finding or with advanced symptoms. This case reported a
69-year-old man with a history of gallstone pancreatitis who presented with recurrent acute
cholecystitis, failed antibiotic treatment, and was treated with open cholecystectomy. Intraop-
eratively gallbladder was embedded in the liver bed with fundal perforation and multiple liver
nodules. Subsequently, we proceed with R2 resection due to the macerated fundal wall of the
gallbladder. Histopathological examination showed a squamous cell carcinoma of the gallbladder
with liver bed invasion. In view of poor ECOG status, the adjuvant treatment was abandoned.
The main aim for this case report is to discuss regarding the best treatment for this patient, as
limited data is available to treat this condition.

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How to Cite
Tilawatu, N., Ezmas , N., & Ahmad, F. . (2026). Challenging Management Of Pure Squamous Cell Carcinoma Of Gallbladder With Liver Metastasis: A Case Report. British Journal Of Surgical Science, 6(1). Retrieved from https://britishjournalofsurgicalscience.uk/index.php/bjoss/article/view/50
Issue
Vol. 6 No. 1 (2026): General Surgery
Section
GENERAL SURGERY
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Author Biographies

N Ezmas , General Surgeon

Department of Surgery, Sultan Ahmad Shah Medical Centre @IIUM, Jalan Sultan Haji Ahmad Shah, Bandar Indera Mahkota, 25200 Kuantan, Pahang, Malaysia

F Ahmad, Pathologist

Department of Pathology, Hospital Sultanah Nur Zahirah, Jalan Sultan Mahmud, 20400 Kuala Terengganu, Terengganu, Malaysia

References

Ayabe RI, Wach MM, Ruff SM, Diggs LP, Martin SP, Wiemken T, et al. Gallbladder squamous

cell carcinoma: An analysis of 1084 cases from the National Cancer Database. Journal of

Surgical Oncology. 2020;122(4):636-42.

Samuel S, Mukherjee S, Ammannagari N, Pokuri VK, Kuvshinoff B, Groman A, et al. Clinico-

pathological characteristics and outcomes of rare histologic subtypes of gallbladder cancer

over two decades: A population-based study. PLoS One. 2018;13(6):e0198809.

Zhu C, Sun L, Wei Y, Xu D, Zhou Y. Characteristics and survival prognosis of patients with

pure squamous cell carcinoma of the gallbladder. ANZ Journal of Surgery. 2021;91(3):E91-7.

Andrea C, Francesco C. Squamous-cell and non-squamous-cell carcinomas of the gallbladder

have different risk factors. Lancet Oncology. 2003;4(7):393-4.

Leigh N, Solomon D, Pletcher E, Sullivan B, Sarpel U, Labow DM, et al. Adenosquamous

and squamous cell carcinoma of the gallbladder: The importance of histology in surgical

management. American Journal of Surgery. 2020;220(5):1242-8.

Perisetti A, Raghavapuram S, Tharian B, Warraich I, Hardwicke F, Rahman R, et al. Pure

squamous cell carcinoma of the gallbladder masquerading as a hepatic mass. Cureus.

;10(1):e2011.

Willson CM, Barsoum N, Khan MTA, Rushton J. Primary squamous cell carcinoma of gallblad-

der with hepatic invasion. Cureus. 2023;15(3):e35795.

Mghirbi F, Ayadi M, Karray W, Yahyaoui Y, Meddeb K, Mokrani A, et al. Squamous cell

carcinoma of the gallbladder. Translational Gastroenterology and Hepatology. 2016;1:78.