Abstract
Acute cholangitis leading to sepsis is a common occurrence, especially in populations with a high
prevalence of gallstones. Unfortunately, the mortality rate related to this issue is high. Recently,
we had a case involving an elderly woman who initially had mild acute cholangitis, but it progressed
into a severe case. Respiratory and hematological issues developed, along with worsening septic
parameters and liver functions. As a result, she was intubated, ventilated, and monitored in the
intensive care unit (ICU). Urgent ERCP failed, but PTBD and percutaneous cholecystostomy were
inserted to aid in biliary decompression and sepsis control. Currently, she is recovering from
sepsis and plans for early ERCP and cholangiogram before definitive surgical intervention. To
handle obstructed biliary sepsis, early biliary drainage is crucial for urgent biliary decompression
and sepsis control, alongside fluid resuscitation, intravenous antibiotics, and intensive care.
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