A Pragmatic Study Of Porcine Acellular Dermal Matrix Mesh In Ventral And Parastomal Hernia Repairs. Evaluation Of Outcomes From A Tertiary Centre.
Main Article Content
Abstract
Aims and Objectives: Incidence of complex ventral hernias and those with contamination are increasing. Synthetic meshes are not favoured due to increased risk of wound complications. Biologic meshes are used as an alternative given their biocompatible safety, but, there is lack of strong evidence to recommend its routine use. Hence, it is up to institutions to evaluate the safety and efficacy to support its continuing usage, which is the basis of this study.
Methods: A retrospective review of a prospectively maintained PADM mesh database was performed focussing on midline and parastomal hernias. Demographic data, surgical techniques and short- and long-term complications were reviewed.
Results: 71cases, (acute/elective 10/61) were included. The median age group, sex ratio in the acute and elective groups were 67 years (36-83yrs) and 62years (25-93yrs), 2:1 and 4:3 respectively. Mean ASA score was 3.4 in acute and 2.4 in elective group. Midline hernias constituted 37/ 61 (60%) and Parastomal hernias, 40% (24/61). Component separation was performed in 29 cases, which includes bilateral anterior component separation in 16, unilateral anterior component in 11 and posterior component separation in 2. Median length of stay was 11days (1-180d) and 15 days (1-159d) in the elective and acute groups respectively. Median length of follow up was 18 months (12 -72 months). There were 5 deaths within 90 days. Recurrences were noted in 6/37 (16%) midline repairs and 8/24 (33%) parastomal hernias.
Conclusion: Our limited PADM series showed acceptable results in comparison with available studies. As such we find it a useful adjunct in the repair of complex ventral hernias.
Downloads
Article Details

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
This is an open-access journal, which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is under the BOAI definition of open access.
The journal is adopting the Creative Commons International Attribution 4. CC Attribution-NonCommercial 4.0CC BY-NC 4.0]
You are free to:
- Share— copy and redistribute the material in any medium or format
- Adapt— remix, transform, and build upon the material
- for any purpose
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
-
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes .
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
- https://creativecommons.org/licenses/by-nc/4.0/
References
Hodgkinson J, Worley G, Warusavitarne J, Hanna G, Vaizey C, Faiz O. Evaluation of the
Ventral Hernia Working Group classification for long-term outcome using English Hospital
Episode Statistics: a population study. Hernia. 2021;25:977-84.
Sandvall BK, Suver DW, Said HK, Mathes DW, Neligan PC, Dellinger EP, et al. Comparison of
synthetic and biologic mesh in ventral hernia repair using components separation technique.
Annals of Plastic Surgery. 2016;76(6):674-9.
Rosen MJ, Krpata DM, Petro CC, Carbonell A, Warren J, Poulose BK, et al. Biologic vs
synthetic mesh for single-stage repair of contaminated ventral hernias: a randomized clinical
trial. JAMA surgery. 2022;157(4):293-301.
Breuing K, Butler CE, Ferzoco S, Franz M, Hultman CS, Kilbridge JF, et al. Incisional ventral
hernias: review of the literature and recommendations regarding the grading and technique
of repair. Surgery. 2010;148(3):544-58.
Hufford T, Tremblay JF, Sheikh MTM, Marecik S, Park J, Zamfirova I, et al. Local parastomal
hernia repair with biological mesh is safe and effective. The American Journal of Surgery.
;215(1):88-90.
Slater N, Montgomery A, Berrevoet F, Carbonell A, Chang A, Franklin M, et al. Criteria for
definition of a complex abdominal wall hernia. Hernia. 2014;18:7-17.
Kanters AE, Krpata DM, Blatnik JA, Novitsky YM, Rosen MJ. Modified hernia grading scale
to stratify surgical site occurrence after open ventral hernia repairs. Journal of the American
College of Surgeons. 2012;215(6):787-93.
Passot G, Villeneuve L, Sabbagh C, Renard Y, Regimbeau JM, Verhaeghe P, et al. Definition of
giant ventral hernias: development of standardization through a practice survey. International
journal of surgery. 2016;28:136-40.
Muysoms F, Campanelli G, Champault G, DeBeaux A, Dietz U, Jeekel J, et al. EuraHS: the
development of an international online platform for registration and outcome measurement
of ventral abdominal wall hernia repair. Hernia. 2012;16:239-50.
Flum DR, Horvath K, Koepsell T. Have outcomes of incisional hernia repair improved with
time?: A population-based analysis. Annals of surgery. 2003;237(1):129.
Luijendijk RW, Hop WC, Van Den Tol MP, De Lange DC, Braaksma MM, IJzermans JN, et al.
A comparison of suture repair with mesh repair for incisional hernia. New England Journal
of Medicine. 2000;343(6):392-8.
Ko JH, Wang EC, Salvay DM, Paul BC, Dumanian GA. Abdominal wall reconstruction:
lessons learned from 200 “components separation” procedures. Archives of surgery.
;144(11):1047-55.
Wegdam J, Thoolen J, Nienhuijs S, De Bouvy N, de Vries Reilingh T. Systematic review of
transversus abdominis release in complex abdominal wall reconstruction. Hernia. 2019;23:5-
Sbitany H, Kwon E, Chern H, Finlayson E, Varma MG, Hansen SL. Outcomes analysis of
biologic mesh use for abdominal wall reconstruction in clean-contaminated and contaminated
ventral hernia repair. Annals of plastic surgery. 2015;75(2):201-4.
Limura E, Giordano P. Biological implant for complex abdominal wall reconstruction: a single
institution experience and review of literature. World Journal of Surgery. 2017;41:2492-501.
Richmond B, Ubert A, Judhan R, King J, Harrah T, Dyer B, et al. Component separation
with porcine acellular dermal reinforcement is superior to traditional bridged mesh repairs
in the open repair of significant midline ventral hernia defects. The American Surgeon.
;80(8):725-31.
Clemens MW, Selber JC, Liu J, Adelman DM, Baumann DP, Garvey PB, et al. Bovine versus
porcine acellular dermal matrix for complex abdominal wall reconstruction. Plastic and
reconstructive surgery. 2013;131(1):71-9.
Morales-Conde S, Hernández-Granados P, Tallón-Aguilar L, Verdaguer-Tremolosa M, López-
Cano M. Ventral hernia repair in high-risk patients and contaminated fields using a single
mesh: proportional meta-analysis. Hernia. 2022;26(6):1459-71.